認知症のリスクをもつ高齢者に対する進展予防を目指した多因子介入によるランダム化比較研究

Greeting

 Welcome to the homepage of J-MINT. I am Hidenori Arai of the National Center for Geriatrics and Gerontology, the principal investigator of J-MINT.

 The number of people with dementia is increasing along with the aging of the population, and dementia is the leading cause of people requiring nursing care. Following the formulation of the "Comprehensive Strategy for the Promotion of Dementia Policies (New Orange Plan) - Toward the Creation of Dementia-Friendly Communities" in January 2015, the "Outline for the Promotion of Dementia Policies" was compiled in June 2019.Specifically, Japan, as the country with the world's longest life expectancy, will send out a message to the world that society as a whole should take action against dementia, and will promote measures based on the two wheels of "coexistence" and "prevention" with the aim of realizing a society where people with dementia can continue to live in their own way in the community as long as possible. In this context, prevention is the most important issue.

 With regard to prevention, diabetes, hypertension, and obesity have been identified as risk factors for dementia, and the FINGER study conducted in Europe has shown that multimodal interventions such as cognitive training in addition to exercise and nutritional improvement can slow down the speed of cognitive decline. In Japan, there is also a need to address the issue of dementia. In Japan, the J-MINT study, which is an intervention study with unique Japanese approaches to verify the preventive effect on dementia, was launched in 2019, led by the National Center for Geriatrics and Gerontology. This study is a multi-center collaborative study to be conducted together with Nagoya University, Nagoya City University, Fujita Medical University, and Tokyo Metropolitan Institute of Gerontology Hospital.

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 The purpose of the J-MINT study is to examine the efficacy of a combined dementia prevention program (a combined intervention of lifestyle disease management, exercise, nutrition, and cognitive training) in reducing cognitive decline in 500 older people at risk for dementia in a randomized controlled trial. During the four-year research period, we will clarify the effect of the combined dementia prevention program on the reduction of cognitive decline, create new services by conducting research in collaboration with private companies, create certification criteria to determine whether existing services are appropriate as dementia prevention services, and create a manual for using ideal services. We also plan to create a system of dementia prevention services that can be widely deployed. In addition, we believe that this research will be able to get closer to the mechanism of the suppression of cognitive decline by conducting biomarker, omics and brain imaging analyses.

 The results of this study will not only establish a standardized approach for older people at high risk for dementia, but will also serve as a starting point for social implementation for dementia prevention. Furthermore, the results are expected to contribute to the extension of healthy life expectancy and improvement of quality of life of older adults, as well as to the realization of the dementia promotion policy, along with improvement to medical standards and the medical economy. We would like to ask for your continued support for J-MINT research.